*Attractive* theory - but scientifically lousy methodology.
So, according to the original study they're buzzing about(if you follow link, after link, after link)
https://www.nature.com/mp/journal/v11/n ... 1805a.html
A VERY small study was done in which a large percentage of participants dropped out. They gave the control group an anti-depressant and a placebo, and gave the experimental group an anti-depressant with celebrex (an NSAID) The group with the NSAID improved their scores on the Hamilton Depression scale.
http://healthnet.umassmed.edu/mhealth/HAMD.pdf
The Hamilton Depression scale says that symptoms of depression are things like back pain, headache and other body pains.
So, guess what. The folks getting a pain killer had less pain, and their "depression" score improved.
Odds are, using this test, if they had used JUST an Nsaid these folks would have gotten "better" on the "depression" scale because their pain would have decreased. (Imagine what a shot of whiskey might have done for their "depression" using this scale
)And the jewel in the objectivity crown here? The study was funded by the manufacturer of Celebrex
https://www.nature.com/mp/journal/v11/n ... 1805a.html (see bottom of page)
https://www.wsj.com/articles/SB1026758902994143760 (Merger & acquisition story)
(Sorry to rain on the parade - just can't help myself
)